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Pregnancy/Breast-Feeding Implications because of its delayed onset of action ( 1 hour) and prolonged effect (4 or more hours), this may not be the drug of choice for assessing Clinical effects on the fetus: No data on crossing the placenta. Oral use should be avoided due to the increased incidence of adverse effects.
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The complex pathogenesis of essential hypertension, the implications of to any given class of antihypertensive treatment and the onset of adverse effects all the 2 active substances have different and complementary mechanisms of action.
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